UCR

Institute for Integrative Genome Biology



Members


Adler DillmanAdler Dillman

Assistant Professor

Mailing Address:

Nematology
Genomics Building /2107B
University of California
Riverside, CA 92521

Phone: (951) 827-3912
Fax: (951) 827-4294
Email: adler.dillman@ucr.edu

Degree(s):

Postdoc 2014 Stanford University
PhD 2013 California Institute of Technology
BSc 2006 Brigham Young University

College/Division Affiliation:

College of Natural and Agricultural Sciences

Center/Inst Affiliation(s):

Center for Disease Vector Research

Areas Of Expertise:

Insect-Parasitic Nematodes; Host-Parasite Interactions; Insect Immunity; Behavioral Ecology

Awards / Honors:

2014  Life Sciences Research Foundation Postdoctoral Fellowship
2013 Lawrence L. and Audrey W. Feguson Prize
2013  John M. Webster Outstanding Student Award
2012  Everhart Lecture Award

Research Summary:

The Dillman lab studies host-parasite interactions from both perspectives, using insect host models. We are interested in how hosts recognize and initiate immune response to parasites and how parasites evade and/or suppress immunity. We study parasite host-seeking behavior and olfaction using parasitic nematodes. To investigate how parasites evade and/or suppress host immunity we are studying which proteins are involved in this process and are working to identify their targets.

From the host perspective we study how nematode parasites are recognized and the immune response their presence elicits. To do this we use a variety of insect hosts. As part of this work we study host immunity generally using bacterial pathogens, nematode parasites, and other immune insults such as cancer. In studying immunity we differentiate the relative roles of resistance, the ability of the host to reduce or eliminate pathogen burden, and disease tolerance or the ability of the host to manage the effects of infections

Figure 1

Figure 1. This shows some of the insect hosts we work with, including earwigs, house crickets, waxworms, and mole crickets. B) Some waxworms infected with insect-parasitic nematodes.

 

Figure 2

Figure 1. An illustration of the life cycle of the parasitic nematodes we use, which are called entomopathogenic nematodes (EPN). The infective juvenile stage (IJ) is a developmentally arrested third larval stage and is the only free-living stage; all other stages exist exclusively within the host. EPN IJs carry symbiotic bacteria and search for potential insect hosts. They enter a host, gain access to the hemolyph and release their bacterial symbiont. The symbiont plays a critical role in overcoming host immunity. The nematodes develop and reproduce in the resulting nutrient-rich environment until population density is high and resources begin to deplete, at which point new IJs develop and disperse, carrying the symbiotic bacteria to new hosts.

 

Selected Publications:

Selected List of publications from PubMed


More Information

General Campus Information

University of California, Riverside
900 University Ave.
Riverside, CA 92521
Tel: (951) 827-1012

Career OpportunitiesUCR Libraries
Campus StatusDirections to UCR

Genomics Information

Institute of Integrative Genome Biology
2150 Batchelor Hall

Tel: (951) 827-7177
E-mail: Aurelia Espinoza, Managing Director

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