UCR

Institute for Integrative Genome Biology



Members


I-Chueh HuangI-Chueh Huang

Assistant Professor

Mailing Address:

Cell Biology and Neuroscience
Biological Sciences Building /3115
University of California
Riverside, CA 92521

Phone: (951) 827-3560
Fax: (951) 827-3087
Email: ichueh.huang@ucr.edu

Degree(s):

PhD 2008 Harvard University
MD 2000 National Taiwan University

College/Division Affiliation:

College of Natural and Agricultural Sciences

Areas Of Expertise:

Viral Entry; Innate Immune Control of Viral Infection

Awards / Honors:

2011 Pilot Research Project Award, Harvard Medical School
2011  Pathway to Independent Award (K99/R00), National Institutes of Health
2010  Ruth L. Kirschstein-National Service Research Award, National Institutes of Health
2010  Muthiah D. Daniel Award for Excellence in Immunology and Infectious Disease, Harvard Medical School 

Research Summary:

Our research objective is to contribute to a comprehensive understanding of the innate immune control of viral infections, and help create novel therapies for viral diseases based on this understanding. Recently, we identified a family of interferon-inducible transmembrane (IFITM) proteins critical to the intrinsic and innate immune control of several highly pathogenic viruses, including SARS coronavirus, influenza A viruses, dengue virus, West Nile virus, Ebola virus, and Marburg viruses. The IFITM protein family has four human paralogs, IFITM1, 2, 3, and 5. As their names indicate, expression of IFITM proteins is strongly induced by both type I and type II interferons. Our studies demonstrated that IFITM proteins restrict viral replication at the early stage of their lifecycles. We also showed that IFITM proteins differentially restrict influenza A viruses and filoviruses. In vivo, IFITM-mediated restriction plays a pivotal role in control of influenza A virus replication. We observed that Ifitm knockout mice developed more severe clinical presentations than wild type mice after challenged with influenza A viruses.  

Based on previous IFITM work, our current research focuses on (1) understanding the mechanisms of IFITM-mediated viral restriction, (2) investigating the role of IFITM proteins in modulation of adaptive immunity, (3) determining the importance of human IFITM polymorphisms in control of viral infections, and (4) identifying compounds which upregulate the expression of IFITM proteins. Several approaches are used in our lab, including flow cytometry, confocal microscopy, immunoprecipitation, siRNA and drug screens, and animal experiments. These studies may (1) deepen our knowledge of how innate immunity controls viral infection and modulates adaptive immunity, (2) identify populations which are sensitive to specific viral infections, (3) help define and limit the use of antivirals, and (4) provide new approaches for the treatment of viral diseases..

Selected Publications:

List of publications from PubMed


Lab Personnel: +

Wu, Wan-Lin
Postgraduate Researcher —
Williams, David
Technician —

More Information

General Campus Information

University of California, Riverside
900 University Ave.
Riverside, CA 92521
Tel: (951) 827-1012

Career OpportunitiesUCR Libraries
Campus StatusDirections to UCR

Genomics Information

Institute of Integrative Genome Biology
2150 Batchelor Hall

Tel: (951) 827-7177
E-mail: Aurelia Espinoza, Managing Director

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