UCR

Institute for Integrative Genome Biology



Members


Fedor KarginovFedor Karginov

Assistant Professor 

Mailing Address:

Cell Biology & Neuroscience
Genomics Building /3119C
University of California
Riverside, CA 92521

Phone: (951) 827-3604
Fax: (951) 827-5155 
Email: karginov@ucr.edu

Degree(s):

PhD Biochemistry 2005  University of Colorado, Boulder
BS Chemistry 1998 University of Virginia

College/Division Affiliation:

College of Natural and Agricultural Sciences

 

Areas Of Expertise:

MicroRNAs; RNA-protein Interactions; RNA-binding Proteins; Post-transcriptional Regulation

Awards / Honors:

2007-09  American Cancer Society Postdoctoral Fellowship
1999-02  National Science Foundation Graduate Fellowship

Research Summary:

Gene expression is elaborately controlled at the post-transcriptional level. Molecularly, this control is accomplished through interactions of small RNAs (microRNAs) and RNA-binding proteins (RBPs) with specific sites on messenger RNAs; these associations affect the stability and translation rates of the mRNAs, altering the protein output. As the cell or its environment changes (for example, in cases of differentiation or stress), the interactions between these factors and mRNAs dynamically rearrange to adjust the expression program. Furthermore, binding of microRNAs or RBPs at nearby sites on the same mRNA allows for additive or synergistic interactions between the regulators themselves, imparting a higher order of combinatorial control. In this way, hundreds of microRNAs and RBPs functioning in mammalian cells set up a post-transcriptional regulatory network.

Our research focuses on understanding the overall mapping and principles of the interactions between mRNAs and their controlling factors - microRNAs and RBPs, and the interplay between these factors. To this end, we employ a mixture of tools in molecular biology, bioinformatics and cell biology. These tools include high-throughput, transcriptome-wide techniques to assess the interaction patterns (CLIP-seq and RNA-seq), as well as targeted studies of individual mRNAs using reporter systems


Selected Publications:

List of publications from PubMed


Lab Personnel: 

Estep, Jason
Laboratory Assistant — Post-transcriptional regulation by microRNAs and RBPs
Li, Yahui
Graduate Student Researcher — Post-transcriptional regulation by microRNAs and RBPs
Sternburg, Erin
Graduate Student Researcher —  Ago-mRNA interactions

More Information

General Campus Information

University of California, Riverside
900 University Ave.
Riverside, CA 92521
Tel: (951) 827-1012

Career OpportunitiesUCR Libraries
Campus StatusDirections to UCR

Genomics Information

Institute of Integrative Genome Biology
2150 Batchelor Hall

Tel: (951) 827-7177
E-mail: Aurelia Espinoza, Managing Director

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