Institute for Integrative Genome Biology


Patricia ManosalvaPatricia Manosalva

Assistant Professor;
Director of the UCR Avocado Rootstock Breeding Program

Mailing Address:

Plant Pathology & Microbiology
Boyce Hall / 3485
University of California
Riverside, CA 92521

Phone: (951) 827-3773
Fax: (951) 827-4294
Email: patricia.manosalva@ucr.edu


PhD Plant Pathology  2006  Kansas State University
MS Biochemistry and Molecular Biology  2001  Cayetano Heredia University
BS Biology  1997  Ricardo Palma University

College/Division Affiliation:

College of Natural and Agricultural Sciences

Center/Inst Affiliation(s):

Center for Plant Cell Biology

Areas Of Expertise:

Molecular Plant-Microbe Interactions; Plant Pathology; Molecular Biology; Plant Resistance; and Plant Genetics and Genomics

Awards / Honors:

2015 Oomycete Molecular Genetics Network (OMGN) travel fellowship for the Oomycete Bioinformatics Training Workshop funded by the USDA
2014 Oomycete Molecular Genetics Network (OMGN) travel fellowship funded by the USDA
2008  Oomycete Molecular Genetics Network (OMGN) travel fellowship funded by the USDA
2004  Don C. Warren Genetic Scholarship, The Don C. Warren Family, Kansas State University

Research Summary:

The primary research goal of my laboratory is to elucidate the molecular and genetic basis of plant immunity against oomycete pathogens with an emphasis on Phytophthora cinnamomi (Pc) in model plants (Arabidopsis) and avocado. The identification of candidate genes associated with resistance against this oomycete pathogen will be a key aspect for the generation of molecular markers for Marker Assisted Selection (MAS) to develop new resistantavocado rootstocks varieties.One of the main goals of my multidisciplinary research program is to apply and incorporate the basic knowledge and information we gain from basic research in my lab into the UCR Avocado Rootstock Breeding program. The UCR avocado breeding program aims to develop a set of genomic tool for avocado breeding worldwide.

Research in my laboratory is focused on:

1) Understanding how the CRT1/MORC1 gene family, a GHKL ATPase, modulates plant immunity against Phytophthora infestans in plants. We found that this gene family functions in multiple layers of plant immunity in Arabidopsis, barley, and Solanaceous crops. In addition, MORC1 is an epigenetic regulator involved in chromatine remodeling.We will use molecular, genetics, and genomics (RNAseq, miRNAs) approaches to understand how this gene family regulates plant immunity to this oomycete pathogen.

2) Elucidating the molecular and genetic basis of plant immunity against Phytophthora cinnamomi (Pc), the causal agent of Phytophthora root rot, the most destructive disease of avocado worldwide. We study plant-Pc. interactions in model plants (Arabidopsis) and crops (Avocado) using molecular, genetic, and genomic approaches including transcriptome analysis.

3) Identifying and characterizing proteins from P. cinnamomi that are critical for pathogen virulence. In addition, we want to understand the molecular basis of the broad host specialization of Pc using comparative genomics.

4) Recently, a new introduction of potentially more aggressive Pc isolates has been found in Southern CA avocado growing areas. We are currently working on the phenotypic and molecular characterization of these Pc isolates.We will study the genetic diversity of this oomycete pathogen in CA and in other countries where this pathogen is a major problem using Next Generation of Sequencing (NGS).


Related Press Releases:

Selected Publications:

List of publications from PubMed

Lab Personnel: +

McKee, Grandon
Staff Research Associate — Field research, Phytophthora cinnamomi, and Avocado Breeding.
Belisle, Rodger
PhD Student — Oomycete biology and oomycete-plant interactions.
Jackson, Natasha
PhD Student — Understanding how MORC gene family regulates plant immunity against Phytophthora infestans in Solanaceous crops.
Baghaei, Arman
Undergraduate Student — Phenotypic characterization of P. cinnamomi isolates.

More Information

General Campus Information

University of California, Riverside
900 University Ave.
Riverside, CA 92521
Tel: (951) 827-1012

Career OpportunitiesUCR Libraries
Campus StatusDirections to UCR

Genomics Information

Institute of Integrative Genome Biology
2150 Batchelor Hall

Tel: (951) 827-7177
E-mail: Aurelia Espinoza, Managing Director