UCR

Institute for Integrative Genome Biology



Members


Ernest MartinezErnest Martinez

Associate Professor of Biochemistry 

Mailing Address:

Biochemistry
Boyce Hall /4434
University of California
Riverside, CA 92521

Phone: (951) 827-2031
Fax: (951) 827-4434
Email: ernest.martinez@ucr.edu 

Website

Degree(s):

PhD 1989 University of Lausanne (Switzerland)

College/Division Affiliation:

College of Natural and Agricultural Sciences

Center/Inst Affiliation(s):

Stem Cell Center

Areas Of Expertise:

Molecular Biology; Biomedical Research; Gene Transcription Regulation by RNA Polymerase II

Awards / Honors:

2005-2010  CAREER Award from The National Science Foundation (USA).
2003-2004  University of California Regents' Faculty Fellowship
1996-00 Research Associate, The Rockefeller University
1995-96 Biomedical Research Fellow of The Charles Revson & Norman and Rosita Winston Foundation, The Rockefeller University
1992-95 PostDoctoral Associate, The Rockefeller University
1990-92 PostDoctoral Fellow of the Swiss National Science Foundation, The Rockefeller University

Research Summary:

My research interest is in the characterization of the factors and molecular mechanisms involved in the regulation of chromatin structure and gene-selective transcription by RNA polymerase II, with emphasis on the control of mammalian cell proliferation and differentiation.
Research in the lab currently focuses on 3 interrelated projects:
  • Analysis of the structure, function, and regulation of human multi protein transcription coregulator complexes including GCN5/PCAF acetylase complexes (such as STAGA).
  • Investigation of the molecular mechanisms involved in the control of gene expression and chromatin/epigenetic modification by the MYC oncoproteins as they relate to MYC-dependent cell proliferation of ´┐Żnormal´┐Ż (e.g. stem or progenitor) cells and cancer cells.
  • Analysis of the basal transcription machinery required for specific transcription of genes with different core promoter structure including the role of chromatin, TAFs, and novel cofactors in core promoter selectivity.

A combination of cellular, molecular biological and biochemical techniques are used, including the reconstitution of transcription regulatory processes in vitro with purified native and recombinant factors and chromatin-assembled physiological target genes

Related Press Releases:

Selected Publications:

List of publications from PubMed

 


More Information

General Campus Information

University of California, Riverside
900 University Ave.
Riverside, CA 92521
Tel: (951) 827-1012

Career OpportunitiesUCR Libraries
Campus StatusDirections to UCR

Genomics Information

Institute of Integrative Genome Biology
2150 Batchelor Hall

Tel: (951) 827-7177
E-mail: Aurelia Espinoza, Managing Director

Footer