UCR

Institute for Integrative Genome Biology



Members


Manuela Martins-GreenManuela Martins-Green

Professor of Cell Biology

Mailing Address:

Cell Biology and Neuroscience
Biological Sciences Building /2117
University of California
Riverside, CA 92521

Phone: (951) 827-2585
Fax: (951) 827-3087
Email: manuela.martins@ucr.edu
UCR Living the Promise Profile (2010)

Degree(s):

PhD 1987 University of California, Davis
MS 1975 University of California, Riverside

College/Division Affiliation:

College of Natural and Agricultural Sciences

Center/Inst Affiliation(s):

Stem Cell Center

Areas Of Expertise:

Cell and Molecular Biology of Healing; Regenerartion and Tumorigenesis

Awards / Honors:

2010  Fellow, American Association for the Advancement of Science (AAAS) 
2007-2008  UCR Academic Personnel Innovative Teaching Award
2007-2008  UCR Academic Senate Distinguished Campus Service Award
2008 Program co-Chair for the Wound Healing Society Annual Meeting
2008 Member  of  the Scientific Advisory Board for the 2008 TERMIS meeting in San Francisco 2006 Abstract selected for the ASCB Press Book
2005 Nominated for the ICOC, CA prop 71 Initiative
2004- AHA panel on cardiovascular biology
2004 Abstract selected for the ASCB Press Book
2004-06 Chair of the Academic Senate for the UCR division of the UC
2003 Main speaker at the Gordon Conference in Vascular Biology, Ventura, CA
2002 Chair, Bioengineering Session at the Wound Healing Society annual meeting
2001- Member, Standing Committee on Women in Cell Biology of the American Society for Cell Biology 
2001 Speaker, Gordon Conference in Wound Repair and Regeneration
2001 Speaker, ASCB 42nd Annual meeting in the Angiogenesis Minisymposium
2001 Abstract selected for the ASCB Press Book
2000 Organizer, pre-meeting sub-group symposium on “The Cell Biology of Chemokines in Host Defense, Wound Healing and Disease for the annual ASCB meeting
2000 Participant as a chemokine expert in a workshop sponsored by the Radiation Research Program, Division of Cancer Treatment and Diagnosis, NCI (see publication generated from this workshop).
1999-2001 NRSA from NCI
1999 Invited Speaker, Keystone Meeting on Chemokines and their Receptors
1998 Speaker, Annual Wound Healing Society Meeting
1998 Nominee, Academic Achievement Junior Award, Women in Cell Biology, ASCB
1998-2002 Dept of Defense Breast Cancer Review Panel, Immunology Study Section #2, 1
1997-1998; 1999-2000 Faculty Development Award, UC Riverside

Research Summary:

My research program focuses on understanding the cell and molecular basis of healing and regenerartion. Our work has three foci:

(1) Normal healing. We study primarily the activation, expression, function and mode of action of chemokines in healing, using animal models and complex human cultures. Our studies have focused on the chemokine Interleukine-8 (IL-8), what agents at the wound site stimulate its expression, the signal-transduction mechanisms by which this expression occurs, and what functions IL-8 performs during the healing process. Our aim is to: (a) Identify commonalities in the signal transduction and transcription activation mechanisms that may lead the way to regulating the expression of chemokines for potential medical applications; (b) test the effects of IL-8 on the principal cellular components of the granulation tissue of wounds -- fibroblasts, myofibroblasts, endothelial cells, keratinocytes and immune cells - accompanied by tests directly to wounds; (c) characterize the function of IL-8 receptor(s) during wound healing.

(2) Impaired healing. Effects of environmental toxicants, especially those present in cigarette smoke. We study the effects of second-hand smoke on: (a) the development of atherosclerosis (a form of impaired healing); (b) delay of skin and cornea wound healing. Our aim here is to identify key processes affected by cigarette smoke and which chemicals in the smoke cause those effects.

(3) Bench to bedside.  We study the effects of a variety of cytokines and growth factors on wound healing with the goal of identifying; (a) single molecules that improve the speed and the quality of healing; (b)  combination of molecules that can be applied together or sequencially to speed healing and improve its quality; (c) to develop mimetics that can potentially perform the same functions in a more specific manner to avoid side effects.

(4) Engineering of human tissues. In order to test the relevance for human biology of some of the hypotheses we have developed in animal systems, we are developing complex tissue cultures using primary human cells. We have already developed a novel human "skin" organ culture that we are now using to study some of the fundamental cell and molecular processes in normal and abnormal healing of skin. We have also developed a system that allows us to test the effects of inflammatory agents on endothelial permeability and we are currently developing an arterial wall model and a lung epithelial/endothelial blod barrier system for studies of atherogenesis induced by first- and second-hand cigarette smoke.


Selected Publications:

List of publications from PubMed

More Information

General Campus Information

University of California, Riverside
900 University Ave.
Riverside, CA 92521
Tel: (951) 827-1012

Career OpportunitiesUCR Libraries
Campus StatusDirections to UCR

Genomics Information

Institute of Integrative Genome Biology
2150 Batchelor Hall

Tel: (951) 827-7177
E-mail: Aurelia Espinoza, Managing Director

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