Institute for Integrative Genome Biology

Chemical Genomics and the Endomembrane System

IIGB Academic Administrator and Associate Research Plant Cell Biologist Glenn Hicks and colleagues have published research in the Proceedings of the National Academy of Sciences that discusses how the endomembrane system plays a critical role in plant development and response to environmental stresses and disease.

Screening nearly 50,000 drug-like compounds, Hicks, Natasha Raikhel and colleagues discovered more than 100 chemicals that impact the endomembrane system in the model plant Arabidopsis thaliana. This high-content screening approach could be useful in predicting the types of molecules affecting the endomembrane system not only in plants but also humans.

Hicks and Raikhel were joined in the research by IIGB researchers Zhenbiao Yang, a professor of cell biology, Michelle Q. Brown and Shingo Nagawa, as well as scientists at the University of Ghent, Belgium and the Scripps Research institute.

Drakakaki G, Robert S, Szatmari A-M, Brown MQ, Nagawa S, Van Damme D, Leonard M, Yang Z, Girke T, Schmid SL, Russinova E, Friml J, Raikhel NV, Hicks GR (2011) Clusters of Bioactive Compounds Target Dynamic Endomembrane Networks in vivo. Proc Natl Acad Sci USA. 108 (43): 17850-17855.

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