Institute for Integrative Genome Biology

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Jeffrey Bachant

Associate Professor of Cell Biology

Mailing Address:

Cell Biology and Neuroscience
Biological Sciences Building /2113
University of California
Riverside, CA 92521

Phone: (951) 827-6473
Fax: (951) 827-3087
Email: jeffrey.bachant@ucr.edu
Website

Degree(s):

PhD 1993 University of Colorado

College/Division Affiliation:

College of Natural and Agricultural Sciences

Center/Inst Affiliation(s):

Center for Plant Cell Biology

Areas Of Expertise:

Mitotic Chromosome Transmission

Awards / Honors:

1996-99 NIH National Research Fellowship Award
1993-94 Cancer League of Colorado Postdoctoral Fellowship
1986-87 University of Colorado Merit Fellowship
1986 Graduated magna cum laude, Honors Program, University of South Carolina
1983-86 Ella Severin Scholarship in the Marine Sciences

Research Summary:

Mitosis is a precisely regulated event during which equivalent sets of chromosomes are partitioned between mother and daughter cells.  Research in this lab is focused on the mechanisms that ensure accurate mitotic chromosome transmission and that make mitotic entry responsive to stressful contingencies.  One area of study is to elucidate how replicated pairs of chromosomes are physically held together, or cohesed, until the onset of chromosome segregation. Cohesive linkages between sister chromatids are thought to enable chromatid pairs to achieve bipolar attachment to the mitotic spindle.  Centromeric regions of chromosomes appear to be specialized sites of sister chromatid association, but the processes that control this aspect of centromere function are not well understood.  We are utilizing the budding yeast S. cerevisiae to investigate how cohesion is regulated at centromeres through the analysis of mutants that disrupt chromatid associations at centric regions.  Other projects are focused on understanding how chromosome segregation is delayed following activation of the checkpoint pathways that allow cells to respond to DNA damage or blocks to DNA replication.  In S. cerevisiae, DNA damage checkpoints prevent chromosome segregation by blocking cells in a pre-anaphase state.  Analysis of this response may illuminate regulatory pressure points controlling mitotic spindle function and the timing of chromosome segregation.

Selected Publications:

Lab Personnel: +

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