People
David Eastmond
Mailing Address:
Cell Biology and NeuroscienceBiological Sciences /2109
University of California
Riverside, CA 92521
Phone: (951) 827-4497
Fax: (951) 827-3087
Email: david.eastmond@ucr.edu
Website
Degree(s):
PhD 1987 University of California, BerkeleyMS 1983 Brigham Young University
BS 1980 Brigham Young University
College/Division Affiliation:
College of Natural and Agricultural SciencesAreas Of Expertise:
Mechanisms of Toxicity and Carcinogenesis of Agricultural and Environmental Chemicals in Humans and Other MammalsAwards / Honors:
2002-present President-Elect for Environmental Mutagen Society1995 Selected for Inclusion in American Men and Women of Science, 1995 Edition
1995 Selected for Inclusion in Who's Who in the West, 1995 Edition
Research Summary:
Research in the Eastmond laboratory focuses on the mechanisms involved in the toxicity and carcinogenesis of environmental and agricultural chemicals. One important goal of this research is to provide information allowing the potential adverse health effects associated with chemical exposure in human populations to be more accurately estimated. Investigations are performed using a variety of chemical, biochemical and molecular approaches with isolated enzyme, cell culture and animal model systems. Currently investigations are underway to study the metabolism and chromosome-damaging effects of several cancer-causing agents including benzene, a widely used industrial chemical and environmental pollutant, ortho-phenylphenol, an extensively used fungicide and disinfectant and N-nitrosodimethylamine, a component of mainstream and environmental tobacco smoke.In addition, the Eastmond laboratory has an active research program in which molecular cytogenetic techniques are used to detect chromosomal alterations occurring in chemically exposed human populations. These human biomonitoring approaches should allow the early detection of genotoxic effects and allow treatment or intervention strategies to be implemented. Studies are currently underway applying fluorescence in situ hybridization with chromosome-specific DNA probes and related immunochemical techniques to detect chromosomal changes occurring in cells isolated from the blood, semen or mouth of humans using tobacco products, exposed occupationally to benzene or employed spraying pesticides.