People
John R. Weger
Mailing Address:
Keen Hall /2022University of California
Riverside, CA 92521
Phone: (951) 827-4953
Fax: (951) 827-2155
Email: jweger@ucr.edu
Degree(s):
MA 1986 University of California, Los AngelesBA 1972 University of California, San Diego
Areas Of Expertise:
DNA Sequencing; Genomic Sequencing; Next Generation Sequencing; Genotyping; Gene ExpressionResearch Summary:
I am interested in applying next-generation and capillary sequencing, microarray, and q-RT PCR technologies to study polymorphisms, gene and small RNA expression, transcriptional and translational regulation, and epigenetics. I have managed and provided genomic analysis services in both academic and private sector core facilities. Much of my research support has emphasized genetic mapping, genomic sequencing, and polymorphism discovery in various human cancers and diseases. I am also interested in introducing new technologies and software, improving processes, and establishing new applications in the core facility environment. Ultimately, I am drawn toward contributing to the elucidation of the mechanisms of development and aging.
Selected Publications:
Hoffman HM, et al. (2001) Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome. Nature Genetics 29: 301-305
Hoffman HM, et al. (2000) Identification of a Locus on Chromosome 1q44 for Familial Cold Urticaria. Am. J. Hum. Genet. 66: 1693-1698.
Kolodner, RD, et al. (1999) Germ-line msh6 Mutations in Colorectal Cancer Families. Cancer Research. 59: 5068-5074.
Zuo L, Weger J, Yang QY, Goldstein AM, Tucker MA, Walder GJ, Hayward N, and Dracopoli NC (1996) Germline mutations in the p16INK4a binding domain of CDK4 in familial melanoma. Nature Genetics. 12: 97-99.
Duffy DL, Healey SC, Chenevix-Trench G, Martin NG, Weger J, Lichter J (1995) Atopy in Australia. Nature Genetics. 12: 260.
Performed all automated sequencing reactions and analysis in: Gonzalez-Cadavid N, Gatti RA, and Neuwirth H (1990) Automated Direct Sequencing of Polymerase Chain Reaction-Amplified Fragments of the Human Ha-ras Gene. Analytical Biochemistry. 191: 359-364.
Weger JR, Pringle RR, and Salser W (1988) An Analysis of the Accuracy of Sequences Read to More than 500 Nucleotides with the ABI 370A Automated Sequencer. DNA Core Facilities Newsletter. 1, Issue 1.
Pringle RR, Weger JR, and Salser W (1988) Automated Nucleotide Sequence Analysis Accuracy is Strongly Dependent Upon Optimum Template Levels and Avoidance of Gel Overload. DNA Core Facilities Newsletter. 1, Issue 1.